Biomarker the predicts that Enzalutamide won't work?

Tony Crispino
Veteran Member

PCAF Founder

Posts: 8,332

Biomarker the predicts that Enzalutamide won't work? Apr 10, 2014 16:56:32 GMT -8

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Post by Tony Crispino on Apr 10, 2014 16:56:32 GMT -8

From the cancer Network wire:

Possible Biomarker for Enzalutamide in Prostate Cancer

"...researchers have identified a potential biomarker that may confer inherent resistance to enzalutamide. The marker, a variant form of the androgen receptor called AR-V7, can be detected in circulating tumor cells (CTCs) that can be obtained with a blood draw from patients prior to the start of the therapy."

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Jerry
Junior Member

Posts: 44

Biomarker the predicts that Enzalutamide won't work? Apr 17, 2014 3:02:37 GMT -8

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Post by Jerry on Apr 17, 2014 3:02:37 GMT -8

...or can be detected by tumor biopsy, which might be easier to catch vs. CTCs...and my experience is that insurance companies are not kind to the CTC test..$$$

There were only 31 patients, but very interesting.

11/09 Dx at Age 44 ----------- 4.03
12/09 DaVinci Surgery,t3b,g9 <.05
2/10 Adj. Radiation ----------- <.05
3/11 PSA Rise/Scans/Spot ---- .09
on Pelvic Bone
4/11 HT/XGEVA/Spot Radiation -- .06

2012 -- <.015 (ADT3 until October)
2013 -- <.015 (off HT entire year)
2014 -- <.015 (off HT entire year)

25 months since last Lupron shot

Eugene
Guest

Biomarker the predicts that Enzalutamide won't work? Apr 17, 2014 17:28:17 GMT -8 via mobile

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Post by Eugene on Apr 17, 2014 17:28:17 GMT -8

I am a prostate cancer patient in the advanced stages. I received enzalutamide after having previously responded well to abiraterone. Enzalutamide did not work at all (PSA kept going up), but my doctor recommended that I stick with the drug for several months before declaring defeat. I wish I had been able to find out ahead of time that enzalutamide was not going to work in my body. If the AR-V7 test had been available, and it could be tested from my circulating cancer cells, I would have definitely wanted to have the test. I probably would have chosen a different treatment.

Post by Tony Crispino on Apr 10, 2014 16:56:32 GMT -8

Post by Jerry on Apr 17, 2014 3:02:37 GMT -8

Post by Eugene on Apr 17, 2014 17:28:17 GMT -8

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