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Post by Tony Crispino on Feb 21, 2014 22:40:30 GMT -8
The Southwest Oncology Group (SWOG) is the consortium that has some of the most valuable trials in PCa therapy and prevention. The Selenium & Vitamin E Cancer Prevention Trial (Select) is a long term trial examining the myth that vitamin E or Selenium can prevent prostate cancer. This trial did not prove good for either supplement. In fact in the news announcement: "Men using these supplements should stop, period. Neither selenium nor vitamin E supplementation confers any known benefits – only risks." SWOG News AnnouncementPlease read This is significant because many over the counter "prostate health" supplements use selenium and Vitamin E. Such being the case these supplements are doing more harm that good. Tony |
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Post by Tony Crispino on Feb 22, 2014 12:59:07 GMT -8
With this announcement, I see some questioning the Select trial in the online community. It is very important to note that natural forms of Se and E were used not synthetic forms. Patients in this trial were provided blindly a placebo or natural Se and E. 35,000 men were tried between 2002 and 2008. Both the Se and the E were provided in the multiple active arms, and placebo was provided in the control arm. No patients were told to go out and buy their own. Anyone speculating that this trial was wrong are proposing hypothesis that is unproven. Several other trials also showed the same results of the Select trial since the trial was stopped because the harms were present. The cause of the increased detection of prostate cancer in the Vitamin E was hyper-elevated detection in blood samples of vitamin E.
Because we know that elevated vitamin E is associated with potentially lethal prostate cancer, any speculation as to the types or synthesis or other elements should only be done in trials. Patients should not derive their own conclusions and start taking these supplements thinking they know they are right and the Select trial is wrong. Men diagnosed with prostate cancer should only supplement vitamin E when blood tests indicate insufficient levels are present.
As with all supplements, you should only supplement after blood tests indicate that you need to. Hyper amounts of supplementing has almost always proven to be harmful. Proper dietary habits are usually enough to keep normal presence in blood.
Early books by Myers, Walsh, and Strum indicated that you could prevent prostate cancer with these supplements. They also indicated that these supplements help fight the disease after it is detected. After these physicians questioned the Select trial later editions of these books removed the suggestions of any benefits to preventing or treating prostate cancer.
Tony
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Post by Tony Crispino on Feb 22, 2014 13:09:35 GMT -8
The form of vitamin E given was dl-alpha tocopheryl acetate, the form of vitamin E found to reduce prostate cancer incidence in the ATBC. Here is the NCI information on the Select trial... www.cancer.gov/newscenter/qa/2008/selectqaIn addition, while Se had no pharmacological effect on prostate cancer, high amounts was associated with increase in diabetes cases. Tony |
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Post by lupronjim on Mar 26, 2014 11:04:49 GMT -8
I was kind of surprised when in the panel discussion, Dr klotz advocated a daily multi-vitamin that has 70% RMD of Selenium and also vitamin E but as Di-Alpha-Tocophery Acetate in the senior tablet that I used to take.
I stopped taking multi's and instead take only the ones currently deemed good for PCa health separately
LupronJim
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Post by Tony Crispino on Mar 26, 2014 13:39:08 GMT -8
Our findings at SWOG on the multi vitamin was that 100% of daily dose was fine. The problem was men were taking high doses of selenium well beyond the recommended daily dose and that was per many books that said this would prevent prostate cancer. Same with Vitamin E. typically 200% to 500% above daily doses were suggested.
They were wrong. A multivitamin is ok. Klotz says 70% of the daily recommended dose is fine and I agree. We get selenium in meats and some veggies and this is a safe level to assure we do not go over the known thresholds that failed in the SELECT trial.
Tony
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