Post by Tony Crispino on Jan 9, 2014 11:56:47 GMT -8
This article, while not prostate cancer specific, touches on lung cancer screening. The suggestion that 1 in 5 screened lung cancers may be indolent shows that the discussion of over diagnosis and over treatment can be found frequently by screening techniques. As we continue to get better and better at detection, it is clear that treatment v. monitoring is lagging behind. Have a read...
Nearly one fifth of lung cancer screenings may have detected indolent cancer.
Lung cancer is something that if it is aggressive, it is a very serious and many times terminal condition. With a mortality rate of 60% at five years it would be hard to tell a patient that they may be able to monitor their lung cancers.
Contrast this with prostate cancer. The overdiagnosis rates are estimated as high as 50%. And the overtreatment rates also a very high number. The survival rate at 5 years for early detected prostate cancer is just about 100%. Watchful Waiting was more for older low life expectancy patients that didn't want to treat their disease radically or they "already had a good life" and were content to let the disease run it's course. can define the Gleason sum and determine risk factors for progression but we can't define with certainty which patients will never progress on even though we know almost all Gleason 6's will progress very slowly and likely never cause a cancer death. But yet it seems that PCa guys, and their physicians, feel the same urgency about treating the disease as lung cancers. This led to the US Preventive Services Task Force to issue a Grade D recommendation in all men regardless of risk factors. Unfortunate because it seems to throw the baby out wit the bath water.
The question remains, "Are we over detecting and over treating prostate cancer". I can say that five years ago programs such as active surveillance were in their infancy. But papers by Pete Carroll, Ballentine Carter, and Lawrence Klotz have changed the thinking significantly. Today I see more patients on AS than I ever have. But I also see Gleason 6 diagnosis end up on an operating table three weeks after detection.
It would be easy to make an argument that this patient was rushed through the process. I don't see how one could ever feel good doing that with a suspected indolent case of lung cancer.
The saga of screening continues...
Tony
Nearly one fifth of lung cancer screenings may have detected indolent cancer.
Lung cancer is something that if it is aggressive, it is a very serious and many times terminal condition. With a mortality rate of 60% at five years it would be hard to tell a patient that they may be able to monitor their lung cancers.
Contrast this with prostate cancer. The overdiagnosis rates are estimated as high as 50%. And the overtreatment rates also a very high number. The survival rate at 5 years for early detected prostate cancer is just about 100%. Watchful Waiting was more for older low life expectancy patients that didn't want to treat their disease radically or they "already had a good life" and were content to let the disease run it's course. can define the Gleason sum and determine risk factors for progression but we can't define with certainty which patients will never progress on even though we know almost all Gleason 6's will progress very slowly and likely never cause a cancer death. But yet it seems that PCa guys, and their physicians, feel the same urgency about treating the disease as lung cancers. This led to the US Preventive Services Task Force to issue a Grade D recommendation in all men regardless of risk factors. Unfortunate because it seems to throw the baby out wit the bath water.
The question remains, "Are we over detecting and over treating prostate cancer". I can say that five years ago programs such as active surveillance were in their infancy. But papers by Pete Carroll, Ballentine Carter, and Lawrence Klotz have changed the thinking significantly. Today I see more patients on AS than I ever have. But I also see Gleason 6 diagnosis end up on an operating table three weeks after detection.
It would be easy to make an argument that this patient was rushed through the process. I don't see how one could ever feel good doing that with a suspected indolent case of lung cancer.
The saga of screening continues...
Tony