ADT and BMD

twolf
Junior Member

Posts: 16

ADT and BMD Aug 24, 2014 18:33:47 GMT -8

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Post by twolf on Aug 24, 2014 18:33:47 GMT -8

Apparently extended ADT may lead to lowering your bone mineral density.
It has always been my assumption that this is dues to the extremely low testosterone level while on ADT rather than the ADT agent.
A urologist is trying to tell me that Degarelix (Firmagon) does not lower your BMD as severely as Lupron does. I can't find any reference to confirm or dispute this.
Comments?

Last Edit: Aug 26, 2014 7:12:33 GMT -8 by twolf

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Tony Crispino
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ADT and BMD Aug 25, 2014 8:02:06 GMT -8

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Post by Tony Crispino on Aug 25, 2014 8:02:06 GMT -8

I can honestly state that the urologist misspoke. [Original poster stated Eligard. This reply if for Eligard]

Eligard is Leuprolide Acetate. So is Lupron. Nothing else added. Both lower testosterone. It is that drop in testosterone that is associated with development of osteoporosis.

I don't really know much else to say? LHRH agonists and GnRH antagonists all lower T levels. They all carry the same side effects of that.

Last Edit: Aug 26, 2014 10:54:50 GMT -8 by Tony Crispino: Disregard for Degarelix

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Allen
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ADT and BMD Aug 25, 2014 16:05:44 GMT -8

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Post by Allen on Aug 25, 2014 16:05:44 GMT -8

He meant degarelix (which is Firmagon). According to the attached meta-analysis, degarelix had a lower risk of joint symptoms and fractures, as well as urinary symptoms and cardiovascular events.

Degarelix better than agonists.pdf (129.33 KB)

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twolf Junior Member Posts: 16	ADT and BMD Aug 26, 2014 7:07:12 GMT -8 Quote Select Post Deselect Post Link to Post Member Give Gift Back to Top Post by twolf on Aug 26, 2014 7:07:12 GMT -8 Yes, I did mean Degarelix, corrected above; thanks Allen.
	Last Edit: Aug 26, 2014 7:13:59 GMT -8 by twolf 9 year Survivor President, North Texas Prostate Cancer Coalition (NTxPCC)

Post by twolf on Aug 24, 2014 18:33:47 GMT -8

Post by Tony Crispino on Aug 25, 2014 8:02:06 GMT -8

Post by Allen on Aug 25, 2014 16:05:44 GMT -8

Post by twolf on Aug 26, 2014 7:07:12 GMT -8

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