Post by Allen on Jul 29, 2014 22:07:27 GMT -8
Statins
Statins may slow down the growth of advanced, high grade androgen-independent PC cells. However, this association has been found only in some epidemiological and retrospective studies, and not all of them. Some researchers believe that health-conscious men are both more likely to take statins and to get PSA tested earlier, which would explain why they show up with less advanced disease. Some lab studies support its role, however. To the extent that they are effective, only the lipid soluble statins may be effective.
Meanwhile, there seems to be few downsides and many potential upsides to taking low doses as part of the cocktail.
Statin Effective Studies:
• Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.
• Aspirin and Statin Nonuse Associated With Early Biochemical Failure After Prostate Radiation Therapy.
• Association of statin use with pathological tumor characteristics and prostate cancer recurrence after surgery
• Statin medication use and the risk of biochemical recurrence after radical prostatectomy
• Statin use and risk of prostate cancer recurrence in men treated with radiation therapy.
• Association of statin and NSAID use with prostate cancer outcomes
• Statin use and risk of prostate cancer in a population of men who underwent biopsy.
• Statin use and fatal prostate cancer: A matched case-control study.
Statin Ineffective Studies:
• Statin use and the risk of recurrence after radical prostatectomy in a cohort of men with inherited and/or early-onset forms of prostate cancer.
• Preoperative Statin Therapy is not Associated with Biochemical Recurrence After Radical Prostatectomy
• Statin and NSAID use and prostate cancer risk.
• Effect of statin use on biochemical outcome following radical prostatectomy.
There are clinical trials in the works that look at combinations of statins with metformin (NCT01561482), and with Celebrex (NCT01220973). Other trials are investigating its use before (NCT00572468, NCT01992042) and after (NCT01759836) surgery. A large controlled prospective study (NCT01687049) is planned in men on Active Surveillance, using red yeast rice as a statin surrogate; the results may provide a more definitive answer.
Safety
Lipid-soluble statins in low doses have a good safety profile, and many have suggested that they be taken routinely to prevent cardiovascular disease. Myopathy and insulin resistance are known side effects.
Statins may slow down the growth of advanced, high grade androgen-independent PC cells. However, this association has been found only in some epidemiological and retrospective studies, and not all of them. Some researchers believe that health-conscious men are both more likely to take statins and to get PSA tested earlier, which would explain why they show up with less advanced disease. Some lab studies support its role, however. To the extent that they are effective, only the lipid soluble statins may be effective.
Meanwhile, there seems to be few downsides and many potential upsides to taking low doses as part of the cocktail.
Statin Effective Studies:
• Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.
• Aspirin and Statin Nonuse Associated With Early Biochemical Failure After Prostate Radiation Therapy.
• Association of statin use with pathological tumor characteristics and prostate cancer recurrence after surgery
• Statin medication use and the risk of biochemical recurrence after radical prostatectomy
• Statin use and risk of prostate cancer recurrence in men treated with radiation therapy.
• Association of statin and NSAID use with prostate cancer outcomes
• Statin use and risk of prostate cancer in a population of men who underwent biopsy.
• Statin use and fatal prostate cancer: A matched case-control study.
Statin Ineffective Studies:
• Statin use and the risk of recurrence after radical prostatectomy in a cohort of men with inherited and/or early-onset forms of prostate cancer.
• Preoperative Statin Therapy is not Associated with Biochemical Recurrence After Radical Prostatectomy
• Statin and NSAID use and prostate cancer risk.
• Effect of statin use on biochemical outcome following radical prostatectomy.
There are clinical trials in the works that look at combinations of statins with metformin (NCT01561482), and with Celebrex (NCT01220973). Other trials are investigating its use before (NCT00572468, NCT01992042) and after (NCT01759836) surgery. A large controlled prospective study (NCT01687049) is planned in men on Active Surveillance, using red yeast rice as a statin surrogate; the results may provide a more definitive answer.
Safety
Lipid-soluble statins in low doses have a good safety profile, and many have suggested that they be taken routinely to prevent cardiovascular disease. Myopathy and insulin resistance are known side effects.
