Post by Allen on Jul 29, 2014 22:35:43 GMT -8
COX-2 Inhibitors
COX-2 Inhibitors block a protein that causes an inflammatory response. All anti-inflammatory drugs (including ibuprofen and aspirin) inhibit COX-2 to some extent. Celecoxib (Celebrex) is the only specific COX-2 inhibitor available by prescription in the US. An inflammatory response may encourage cancer survival.
Although early results in animal models and in small scale trials looked promising, the first large scale, controlled study (the STAMPEDE trial) of celecoxib+hormone therapy vs hormone therapy alone showed no benefit to celecoxib (Celebrex). Whether or not it may have a synergistic effect with other ingredients in a cocktail (e.g., statins) remains to be seen.
• Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer
• Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence
• Regression of Prostate Tumors upon Combination of Hormone Ablation Therapy and Celecoxib in vivo
• Phase II trial of celecoxib in prostate-specific antigen recurrent prostate cancer after definitive radiation therapy or radical prostatectomy.
• Celecoxib versus placebo for men with prostate cancer and a rising serum prostate-specific antigen after radical prostatectomy and/or radiation therapy.
Safety
Celebrex seems to lack the heart damaging effects that other members of this class have. It is routinely prescribed for arthritis.
COX-2 Inhibitors block a protein that causes an inflammatory response. All anti-inflammatory drugs (including ibuprofen and aspirin) inhibit COX-2 to some extent. Celecoxib (Celebrex) is the only specific COX-2 inhibitor available by prescription in the US. An inflammatory response may encourage cancer survival.
Although early results in animal models and in small scale trials looked promising, the first large scale, controlled study (the STAMPEDE trial) of celecoxib+hormone therapy vs hormone therapy alone showed no benefit to celecoxib (Celebrex). Whether or not it may have a synergistic effect with other ingredients in a cocktail (e.g., statins) remains to be seen.
• Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer
• Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence
• Regression of Prostate Tumors upon Combination of Hormone Ablation Therapy and Celecoxib in vivo
• Phase II trial of celecoxib in prostate-specific antigen recurrent prostate cancer after definitive radiation therapy or radical prostatectomy.
• Celecoxib versus placebo for men with prostate cancer and a rising serum prostate-specific antigen after radical prostatectomy and/or radiation therapy.
Safety
Celebrex seems to lack the heart damaging effects that other members of this class have. It is routinely prescribed for arthritis.